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pentobarbital will reduce the extent or outcome of aprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital and olopatadine intranasal equally maximize sedation. Steer clear of or Use Alternate Drug. Coadministration boosts hazard of CNS despair, which can lead to additive impairment of psychomotor functi